GLOBAL PROTEIN CONJUGATION BY UBIQUITIN-LIKE-MODIFIERS DURING ISCHEMIC STRESS IS REGULATED BY MICRORNAS AND CONFERS ROBUST TOLERANCE TO ISCHEMIA.

Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

Hibernation torpor provides an excellent model of natural tolerance to ischemia.We have previously shown that massive global SUMOylation occurs during hibernation torpor in ground squirrels.We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to ox

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Satisfaction with job and life and remote work in the COVID-19 pandemic: the role of perceived stress, self-efficacy and self-esteem

Introduction The aim of the study was to assess the relationship between performing remote work during the COVID-19 pandemic and the level of job and life satisfaction, as well as the assumed, intermediary role of the level of perceived stress and such resources as self-efficacy and self-esteem.Material and methods The study, implemented with the u

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Schwannoma of the urinary bladder: a case report

Bladder schwannomas are exceedingly rare, benign or malignant, nerve sheath Bookcases tumors that are most often discovered in patients with a known diagnosis of Neurofibromatosis type 1 (NF1).A few sporadic case reports of bladder schwannoma have been published in urologic, obstetric/gynecologic, and pathologic journals.We report a case of an isol

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Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.

During tissue development, patterns of gene expression determine the spatial arrangement of cell types.In many cases, gradients of secreted signalling molecules-morphogens-guide this process by controlling downstream transcriptional networks.A mechanism commonly used in these networks to convert the continuous information provided by the gradient i

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State and Civil Society: Peculiarities of the German Approach

The article is dedicated to the interaction between the German state and civil society (CS).Germany is Work Training western known as a developed democratic state with a strong CS in which non-governmental organizations play an active role.They also help the German government to implement its foreign policy vision and maintain its image abroad.The

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